CLUSTAL O(1.2.4) multiple sequence alignment NL63 -----------------------MASVNWAD-DRAARKKFPP-------PSFYMPLLVSS 29 MERS ------MASPAAPRAVSFADNNDITNTN----LSRGRGRNPKPRAAPNNTVSWYTGLTQH 50 SARS-CoV-2 MSDNGPQ-NQRNAPRITFGGPSDSTGSNQNGERSGARSKQRRPQGLPNNTASWFTALTQH 59 SARS MSDNGPQSNQRSAPRITFGGPTDSTDNNQNGGRNGARPKQRRPQGLPNNTASWFTALTQH 60 :. * .* : : *.. NL63 DKAPYRVIPRNLVPIGK-GNKDEQIGYWNVQER-WRMRRGQRVDLPPKVHFYYLGTGPHK 87 MERS GKVPLTFPPGQGVPLNANSTPAQNAGYWRRQDRKINTGNG-IKQLAPRWYFYYTGTGPEA 109 SARS-CoV-2 GKEDLKFPRGQGVPINTNSSPDDQIGYYRRATRRIRGGDGKMKDLSPRWYFYYLGTGPEA 119 SARS GKEELRFPRGQGVPINTNSGPDDQIGYYRRATRRVRGGDGKMKELSPRWYFYYLGTGPEA 120 .* . : **:. . :: **:. * . * :* *: :*** ****. NL63 DLKFRQRSDGVVWVAKEGAKTVNT-SLGNRKRNQKPL-EP--KFSIALPPELSVVEFEDR 143 MERS ALPFRAVKDGIVWVHEDGATDAPS-TFGTRNPNNDSAIVTQFAPGTKLPKNFHIEGTGGN 168 SARS-CoV-2 GLPYGANKDGIIWVATEGALNTPKDHIGTRNPANNAAIVLQLPQGTTLPKGFYAEGSRGG 179 SARS SLPYGANKEGIVWVATEGALNTPKDHIGTRNPNNNAATVLQLPQGTTLPKGFYAEGSRGG 180 * : .:*::** :** . . :*.*: :. . ** : . NL63 SNNSSRASSRSSTRNNSRDSSRSTSRQQSRTRSDSNQSSSDLVAAVTLALKNLGFDNQSK 203 MERS SQSSSRASSL--SRNSSRSSSQGSRSGNSTRGTSPGPSGI---GAVGGDLLYLDLLNRLQ 223 SARS-CoV-2 SQASSRSSSR--SRNSSRNSTPGSSRGTSPARMA---GNG---GDAALALLLLDRLNQLE 231 SARS SQASSRSSSR--SRGNSRNSTPGSSRGNSPARMA---SGG---GETALALLLLDRLNQLE 232 *: ***:** :*..**.*: .: * .. . . * *. *: : NL63 SPSSSGTSTPKKPNKPLSQPRADKPSQLKKPRWKRVPTREENVIQCFG---PRDFNHNMG 260 MERS ALES-GKV---KQSQPKVITKKDAAAAKNKMRHKRTSTKSFNMVQAFGLRGPGDLQGNFG 279 SARS-CoV-2 SKMS-GKG---QQQQGQTVTKKSAAEASKKPRQKRTATKAYNVTQAFGRRGPEQTQGNFG 287 SARS SKVS-GKG---QQQQGQTVTKKSAAEASKKPRQKRTATKQYNVTQAFGRRGPEQTQGNFG 288 : * *. : .: : . :* * **. *: *: *.** * : : *:* NL63 DSDLVQNGVDAKGFPQLAELIPNQAALFFDSEVSTDEVG------DNVQITYTYKMLVAK 314 MERS DLQLNKLGTEDPRWPQIAELAPTASAFMGMSQFKLTHQNNDDHGNPVYFLRYSGAIKLDP 339 SARS-CoV-2 DQELIRQGTDYKHWPQIAQFAPSASAFFGMSRIGMEVTP------SGTWLTYTGAIKLDD 341 SARS DQDLIRQGTDYKHWPQIAQFAPSASAFFGMSRIGMEVTP------SGTWLTYHGAIKLDD 342 * :* : *.: :**:*:: *. :*:: *.. : * : : NL63 DNKNLPKFIE-------QISAFTKPSSIKEMQS-----QSSHVAQNTVLNASIP------ 356 MERS KNPNYNKWLELLEQNIDAYKTFPKKEKKQKAPKEESTDQMSEPPKEQRVQGSITQRTRTR 399 SARS-CoV-2 KDPNFKDQVILLNKHIDAYKTFPPTEPKKDKKKKAD--ETQALPQRQ----------KKQ 389 SARS KDPQFKDNVILLNKHIDAYKTFPPTEPKKDKKKKTD--EAQPLPQRQ----------KKQ 390 .: : . : .:* . :. . : . :. NL63 -E--SKPLADDDSAIIEIVNEVLH-------- 377 MERS PSVQPGPMIDVNTD------------------ 413 SARS-CoV-2 QTVTLLPAADLDDFSKQLQQSMSSADSTQA-- 419 SARS PTVTLLPAADMDDFSRQLQNSMSGASADSTQA 422 * * :